Posts by: Joana Carvalho

Joana Carvalho

Joana holds a BSc in Biology, a MSc in Evolutionary and Developmental Biology and a PhD in Biomedical Sciences from Universidade de Lisboa, Portugal. Her work has been focused on the impact of non-canonical Wnt signaling in the collective behavior of endothelial cells — cells that made up the lining of blood vessels — found in the umbilical cord of newborns.

February 3, 2021February 3, 2021

EMA Plans Speedy Review of Cilta-cel, CAR T-cell Therapy for Advanced Myeloma

News

An accelerated review will be given an application for European Union approval of ciltacabtagene autoleucel (cilta-cel), a potential CAR T-cell therapy for heavily pre-treated multiple myeloma patients, its developer, Janssen, announced. An accelerated ... Read more

January 27, 2021January 27, 2021

Jakafi Plus Steroid Continuing to Treat Multiple Myeloma in Phase 1 Trial

News

Combining the corticosteroid methylprednisolone and Jakafi (ruxolitinib), an approved oral therapy for bone marrow disorders, is showing promising effectiveness in heavily pre-treated multiple myeloma patients in an ongoing Phase 1 trial. ... Read more

December 11, 2020December 11, 2020

Roche’s Cevostamab Leads to Durable, Deep Responses in Heavily Pre-Treated Patients

News

Cevostamab (BFCR4350A), a bispecific antibody developed by Roche, induces durable and deep responses in heavily pre-treated patients with relapsed or refractory multiple myeloma, according to early data from a Phase ... Read more

October 23, 2020October 23, 2020

Oncopeptides Will Seek Conditional Approval of Melflufen in Europe

News

Oncopeptides soon will seek conditional approval of melflufen (melphalan flufenamide) in the EU for the treatment of relapsed or refractory multiple myeloma. The pharmaceutical company now is planning to submit its application ... Read more

October 19, 2020October 19, 2020

1st Patient Dosed With Investigational T-cell Therapy NEXI-002 in Phase 1/2 Trial

News

NexImmune has dosed the first patient participating in its Phase 1/2 trial of NEXI-002, the company’s investigational T-cell therapy for multiple myeloma. The trial (NCT04505813), which is recruiting participants at ... Read more

October 12, 2020October 12, 2020

NCI Awards $1.7M for Bone Therapy Research to Prevent or Delay Cancer Relapse

News

The National Cancer Institute (NCI) has awarded $1.7 million to support the work of a University of Arkansas for Medical Sciences (UAMS) researcher in developing a therapy that can preserve ... Read more

September 23, 2020September 23, 2020

Ide-cel Granted FDA Priority Review for Heavily-treated Multiple Myeloma

News

The U.S. Food and Drug Administration (FDA) has granted priority review to Bristol Myers Squibb and Bluebird Bio‘s application requesting the approval of idecabtagene vicleucel (ide-cel) for the treatment of adults with multiple ... Read more

September 14, 2020September 14, 2020

FDA Puts on Hold Phase 1 Cellectis Trial Testing CAR T-cell Therapy UCARTCS1A

News

A Phase 1 trial assessing Cellectis’ investigational CAR T-cell therapy, UCARTCS1A, for the treatment of relapsed or refractory multiple myeloma has been placed on hold by the U.S. Food and Drug ... Read more

July 20, 2020August 6, 2020

FDA Office Favors Antibody-drug Conjugate for Advanced Multiple Myeloma

News

An office of the U.S. Food and Drug Administration (FDA) has recommended that belantamab mafodotin, GlaxoSmithKline’s investigational antibody-drug conjugate, be approved for heavily pretreated relapsed or refractory multiple myeloma patients. The ... Read more

July 16, 2020July 16, 2020

Reolysin-Kyprolis Combo Elicits Promising Clinical Responses in Phase 1B Trial

News

When given in combination with Kyprolis (carfilzomib), the investigative therapy Reolysin (pelareorep) elicits a strong inflammatory response — and promising clinical responses — in people with relapsed or refractory multiple myeloma, a Phase ... Read more