News

CAR T-cell therapy Carvykti shows promise in early myeloma

A single infusion of the CAR T-cell therapy Carvykti (ciltacabtagene autoleucel) was sufficient to control disease activity in most multiple myeloma patients who hadn’t fully responded to a standard autologous stem cell transplant (ASCT). That’s according to new data from the 17 patients in cohort D of the…

Sarclisa under FDA priority review as first-line myeloma therapy

The U.S. Food and Drug Administration (FDA) has granted priority review to Sanofi’s application of Sarclisa (isatuximab) in combination with standard of care for treating people newly diagnosed with multiple myeloma who aren’t eligible for a transplant. Priority review is given to therapies that target serious medical conditions…

Bortezomib dosing once a week safer than twice a week: Study

Once-weekly induction therapy with bortezomib is as efficient as the standard two times a week dosing in people newly diagnosed with multiple myeloma, a large retrospective real-world study suggests. No differences were seen between both regimens regarding survival overall and the time patients lived without disease progression, but the…

CAR T-cell therapy NXC-201 given orphan drug status in EU

NXC-201, an investigational CAR T-cell therapy, has been designated an orphan drug in the European Union (EU) as a potential treatment of multiple myeloma. This status aims to speed the therapy’s clinical development by providing incentives that include reduced regulatory fees. It also gives access to the EU centralized…

Abecma OK’d in US to take earlier in treatments for multiple myeloma

The U.S. Food and Drug Administration (FDA) has expanded the indication of Abecma (idecabtagene vicleucel) to allow its use earlier in the therapy regimen for adults with difficult-to-treat multiple myeloma. The CAR T-cell therapy, developed by Bristol Myers Squibb (BMS) and 2seventy bio, was already approved in…