Joana Carvalho, PhD, managing science editor —

The European Commission (EC) has approved Empliciti (elotuzumab) in combination with Pomalyst (pomalidomide) and low-dose dexamethasone for the treatment of adults with relapsed and refractory multiple myeloma. The therapy, collectively known as the EPd combo, is intended for patients who received at least…

Using a combination of CAR T-cell therapies to target different cancer molecules appears to be a feasible and promising way of treating  relapsed or refractory multiple myeloma, a study reports. The findings of the study, “A combination of humanised anti-CD19 and anti-BCMA CAR T cells in patients with relapsed…

The Committee for Medicinal Products for Human Use (CHMP), a branch of the European Medicines Agency (EMA), has recommended that Empliciti (elotuzumab) in combination with Pomalyst (pomalidomide) and low-dose dexamethasone be approved to treat adults with relapsed or refractory multiple myeloma in Europe. The…

Janssen has asked the U.S. Food and Drug Administration (FDA) to approve a new subcutaneous (under-the-skin) formulation of Darzalex (daratumumab) as a faster and easier treatment for people with multiple myeloma. Currently, Darzalex is approved as an intravenous infusion into a vein that takes several hours.

The U.S. Food and Drug Administration (FDA) has approved — with conditions — Xpovio (selinexor) tablets, in combination with the corticosteroid dexamethasone, for the treatment of adults with relapsed or refractory multiple myeloma who received at least four prior therapies and failed to respond to…

Scientists discovered a set of genes that work as an “on/off switch” for malignant multiple myeloma cancer cells, which may shed light into new therapeutic targets for the disease, and for other types of cancers with a higher tendency to spread to bones. The findings of the study, “…

The U.S. Food and Drug Administration (FDA) has approved Janssen‘s Darzalex (daratumumab), used in combination with Revlimid (lenalidomide) and dexamethasone, to treat patients newly diagnosed with multiple myeloma who are ineligible to receive an autologous stem cell transplant (ASCT).

Selinexor in combination with dexamethasone and Pomalyst (pomalidomide) leads to strong and durable anti-cancer responses, without significant side effects, in patients with relapsed or refractory multiple myeloma who received at least two prior therapies, data from a Phase 1/2b trial show. The findings were presented in a…

CT103A, a fully-human anti-B-cell mature antigen (BCMA) CAR T-cell therapy, leads to strong anti-cancer responses in patients with relapsed or refractory multiple myeloma, including those who relapsed after receiving prior CAR T-cell therapy, data from a trial shows. The findings were presented in a poster, titled “…

Ygalo (melflufen) combination therapy continues to lead to clinically meaningful responses, without significant side effects, in patients with relapsed or refractory multiple myeloma, updated data from Phase 1/2 trials show. The new findings were presented in two posters, titled “ANCHOR (OP-104): A Phase 1 study update…