News

Genmab has announced positive results from its Phase 3 POLLUX study investigating the efficacy of daratumumab, in combination with lenalidomide and dexamethasone, to treat patients with relapsed or refractory multiple myeloma, compared to lenalidomide and dexamethasone alone. The ongoing trial met its primary endpoint, with treated patients demonstrating improved progression-free survival, indicating that the…

Ajai Chari, MD, director of clinical research in the Multiple Myeloma Program at the Icahn School of Medicine at Mount Sinai in New York, and Navneet Majhail, MD, MS, director of the Blood & Marrow Transplant Program at Cleveland Clinic, recently shared their views and analyses of two studies investigating the role and…

Leisure-time physical activity is associated with a lower risk for many types of cancer, including a 17 percent lower risk for myeloma. These key findings were independent of body size or smoking history, indicating that it is essential to educate inactive adults of the benefits of physical activity, with an emphasis on its influence…

Newton, Massachusetts-based Karyopharm Therapeutics has published the results from its Phase 1 trial of selinexor (KPT-330) in patients with advanced solid tumors in the Journal of Clinical Oncology, revealing clinically significant anti-tumor activity for the drug. These results will serve as a basis for further clinical trials in multiple…

Three organizations — CURE Media Group, Multiple Myeloma Research Foundation (MMRF) and Takeda Oncology — joined together in the Moving Mountains for Multiple Myeloma fundraiser to support multiple myeloma (MM) research. As a recent second event in this program, 12 MM patients, doctors, family members, and caregivers hiked the Bright…

Bristol-Myers Squibb (BMS) Company and AbbVie have announced that the European Commission (EC) has approved Empliciti™ (elotuzumab) for the treatment of multiple myeloma in combination with Revlimid™ (lenalidomide) and dexamethasone for patients hho received prior therapy at least once. The U.S. Food and Drug Administration had already approved…

The Institute for Clinical and Economic Review (ICER), an independent nonprofit based in Boston that analyzes the value of drugs and other medical services, has released a new report detailing the clinical effectiveness, long-term cost-effectiveness, and potential budget impact of treatments for multiple myeloma (MM). The report, “Treatment Options for Relapsed or Refractory…

Takeda Pharmaceutical Co. has announced that Ninlaro (ixazomib), combined with lenalidomide and dexamethasone as a therapeutic approach for relapsed and/or refractory multiple myeloma (MM), markedly increases a patient’s progression free survival, according to the results of a Phase 3 clinical trial, published as “Oral Ixazomib, Lenalidomide, and…

Researchers in the Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have developed a new animal model of multiple myeloma, which will hopefully allow researchers to better understand the pathology and physiology involved in the development of the disease and test new potential therapeutic agents. The…

A subunit of a signaling protein may be a new therapeutic target in multiple myeloma (MM), a hematologic malignancy with high relapse rates and resulting drug resistance in patients, according to  researchers at the Tokyo Women’s Medical University. The study, “Histone deacetylase inhibitor panobinostat induces calcineurin degradation in multiple myeloma,” published in …