News

German Agency Questions Benefit of Empliciti Reported in Multiple Myeloma Study

Empliciti (elotuzumab), a monoclonal antibody, is approved in both the U.S. and Europe as a treatment, in combination with Revlimid (lenalidomide) and Decatron (dexamethasone), for multiple myeloma patients who have received at least one prior treatment. But the German Institute for Quality and Efficiency in Health and Care (IQWiG) announced  that an early benefit assessment was unable to…

FDA Names Darzalex ‘Breakthrough Therapy’ for Previously Treated Multiple Myeloma Patients

The U.S. Food and Drug Administration has designated Darzalex (daratumumab), in combination with standard-of-care regimens, a breakthrough therapy for people with previously treated multiple myeloma (MM), speeding its clinical development and regulatory review for these patients. The FDA designation is reserved for treatments showing early evidence in clinical studies of substantial improvement over…

Drug Combo for Multiple Myeloma Fails in Overall Patient Survival

A randomized Phase 3 clincal trial has concluded that combining bortezomib (Velcade) with pegylated liposomal doxorubicin (PLD) does not show benefit in treating relapsed or refractory multiple myeloma (MM) patients, compared to bortezomib alone. The data was published in Cancer under the title “Final overall survival results…

Immunotherapy Helps Myeloma Patients Who Relapse After Stem Cell Transplant, Study Shows

Many patients with blood cancers, such as myeloma, go into remission after receiving a stem-cell transplant. However, there are still many patients (about one-third) who relapse, a condition usually associated with a poor prognosis. Dana-Farber Cancer Institute researchers tested the effects of a new treatment approach using repeated doses of the immunotherapy drug Yervoy (ipilimumab), showing…

Elevated BMI Linked to Multiple Myeloma Development and Progression

A study has uncovered that elevated body mass index (BMI), a measurement of obesity, increases an individual’s risk of developing multiple myeloma and the disease’s risk of progression. The study, “Adipocytes contribute to the growth and progression of multiple myeloma: Unraveling obesity related differences in adipocyte signaling,” was recently published…