Kyprolis

January 14, 2019

First Patient Treated with Phase 1 Trial Combo of Reolysin, Opdivo, and Kyprolis

News

A Phase 1 trial of the combination of Reolysin (pelareorep), Kyprolis (carfilzomib), and Opdivo (nivolumab) in relapsed multiple myeloma treated the first patient. The open-label, dose escalation study (NCT03605719) will ... Read more

August 30, 2018August 30, 2018

Amgen Seeks Expanded Approval of Kyprolis to Once-weekly Regimen for Relapsed Myeloma

News

Amgen is seeking to expand the approval of its proteasome inhibitor Kyprolis (carfilzomib) in the U.S. to include once-weekly dosing combined with dexamethasone for multiple myeloma patients with hard-to-treat disease or ... Read more

July 6, 2018

Kyprolis Label to Include Positive Data of Aspire Trial in Advanced Multiple Myeloma Patients

News

Prescribing information for Kyprolis (carfilzomib) in the U.S. will now include positive survival data from the ASPIRE Phase 3 clinical trial, which found treatment significantly lowered a risk of death ... Read more

June 27, 2018

Trial of Virus Combo to Treat Multiple Myeloma Adding Keytruda to Mix for Patient Group

News

A Phase 1b trial testing a combination of Reolysin (pelareorep), Velcade (bortezomib) and dexamethasone in multiple myeloma patients who failed to respond to previous therapy is opening a new treatment group ... Read more

June 11, 2018

Amgen, MD Anderson Collaborate to Advance Early-stage Treatments for Myeloma, Other Cancers

News

Two multi-year collaborative agreements were recently established by Amgen and the University of Texas MD Anderson Cancer Center to advance the development of early-stage investigative therapies in Amgen’s portfolio ... Read more

January 12, 2018January 12, 2018

Multiple Myeloma Patients Remain On Treatment Far Less than in Clinical Trials, Study Finds

News

Patients with relapsed or refractory multiple myeloma who are treated with new therapy combinations remain on their treatments far shorter than those participating in clinical trials, a study found. ... Read more

November 27, 2017November 27, 2017

Adaptive Biotechnologies, Amgen Partner in Phase 3 CANDOR Trial for Multiple Myeloma

News

Adaptive Biotechnologies has partnered with Amgen to use Adaptive’s NGS-based clonoSEQ Assay in a Phase 3 clinical trial led by Amgen to measure minimal residual disease (MRD) status in ... Read more

October 30, 2017October 30, 2017

Pomalyst Is More Cost-effective Than Darzalex or Kyprolis for Heavily Treated Myeloma Patients, Study Reports

News

A combination of Pomalyst (pomalidomide) and low-dose dexamethasone is cheaper than either Darzalex (daratumumab) or Kyprolis (carfilzomib) alone as a treatment for relapsed or refractory multiple myeloma (RRMM), a study shows. ... Read more

October 25, 2017

Advanced Myeloma Patients Live Longer Before Disease Worsens on Once-weekly Dose of Kyprolis, ARROW Trial Shows

News

Patients with relapsed and refractory multiple myeloma lived roughly 3.6 months longer without their disease worsening when they received a once-weekly dose of Amgen’s Kyprolis (carfilzomib) compared to a twice-weekly dose, ... Read more

September 6, 2017

Long-term Data Confirms Kyprolis Survival Benefit in Relapsed Myeloma Patients

News

New long-term data from the Phase 3 ENDEAVOR trial has shown that relapsed multiple myeloma patients treated with Kyprolis (carfilzomib) plus dexamethasone survive a median of nine months longer than ... Read more

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